Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Results of the PETHEMA PCR-LMA Study

This study shows high concordance between NPM1 and IDH results using PCR and NGS. However, sensible important discrepancies are observed for FLT3 mutations. In our context, rapid screening for these druggable mutations should be performed by conventional PCR.

Authors

Institutions

Publication Details

Journal
Cancers
Published
2025-03-01
DOI
https://doi.org/10.3390/cancers17050854
Citations
1
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
1.77

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Results of the PETHEMA PCR-LMA Study

Pilar Martínez‐Sánchez, Eva Barragán, Pau Montesinos, Rebeca Rodríguez‐Veiga et al.
1 citations
Cancers
Acute Myeloid Leukemia Research
1.77
article

Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Results of the PETHEMA PCR-LMA Study

Pilar Martínez‐Sánchez, Eva Barragán, Pau Montesinos, Rebeca Rodríguez‐Veiga, Esperanza Lavilla, Esther Prados de la Torre, Mar Tormo, Elena Soria‐Saldise, David Martínez‐Cuadrón, María José Sayas-Lloris, Juan Manuel Alonso‐Domínguez, Jorge Labrador, Claudia Sargas, Lorenzo Algarra, Joaquín Martínez‐López, Irene Navarro, María José García-Pérez, María José Larráyoz, Josefina Serrano, Cristina Gil, Estrella Carrillo‐Cruz, Ramón García‐Sánz, Cristina Bilbao, Juan Bergua, Teresa Bernal, Blanca Boluda, Jane R. Moran, Carmen Chillón, Rosa María Ayala, María Teresa Gómez‐Casares, Joaquín Sánchez‐García, Pilar Herrera‐Puente, María García‐Fortes, Josè Antonio Pérez-Simón, Marı́a José Calasanz, Manuel Barrios, María Teresa Olave, Raimundo García, Ana Oliva, María Luz Amigo, Esther Pérez‐Santaolalla, Natalia Alonso-Vence, Yolanda Mendizabal
article en
1 citations

Abstract

This study shows high concordance between NPM1 and IDH results using PCR and NGS. However, sensible important discrepancies are observed for FLT3 mutations. In our context, rapid screening for these druggable mutations should be performed by conventional PCR.

CancersVol. 17(5)
Instituto de Salud Carlos III (ES), Hospital Universitari i Politècnic La Fe (ES), Hospital Universitario Nuestra Señora de Candelaria (ES), Hospital General Universitario Morales Meseguer (ES), Instituto Maimónides de Investigación Biomédica de Córdoba (ES), Hospital Clínico Universitario de Valencia (ES), Hospital Universitario de Gran Canaria Doctor Negrín (ES), Biogipuzkoa Health Research Institute (ES), Hospital Universitario 12 De Octubre (ES), Hospital Doctor José Molina Orosa (ES), Hospital San Pedro de Alcántara (ES), Complejo Hospitalario de Jaén (ES), Hospital Universitario Reina Sofía (ES), Hospital General Universitari de Castelló (ES), Hospital Universitario Doctor Peset (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Instituto de Investigación Biomédica de Salamanca (ES), Hospital Clínico Universitario Lozano Blesa (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Centro de Investigación del Cáncer (ES), Hospital Universitario Puerta del Mar (ES), Hospital Universitario Lucus Augusti (ES), Hospital General Universitario de Albacete (ES), Complejo Hospitalario Torrecárdenas (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Clínico Universitario Virgen de la Victoria (ES), Centro de Investigación Biomédica en Red de Cáncer (ES), Hospital Universitario Ramón y Cajal (ES), Instituto de Investigación Sanitaria La Fe (ES), Instituto de Investigación Sanitaria del Principado de Asturias (ES), Universidad de Sevilla (ES), Universidad de Navarra (ES)
Instituto de Salud Carlos III
Openalex Percentile: Top 18%
Acute Myeloid Leukemia Research
1.77
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.