NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression
Here, we revealed NONO-regulated AS of PTEN mRNA in an m<sup>5</sup>C-dependent manner, resulting in the downregulation of PTEN expression in gastric cancer (GC).This study unveils a novel regulatory mechanism of tumor suppressor gene inactivation mediated by m<sup>5</sup>C modification and related alternative splicing in cancer.
Authors
- Houji Song
- Zini Lin
- Hongjuan Cui (ORCID: https://orcid.org/0000-0003-1178-1570)
- Dan Qi (ORCID: https://orcid.org/0000-0001-7015-1849)
- Liping Zhong (ORCID: https://orcid.org/0000-0002-2721-9585)
- Gaichao Zhao
- Lingjun Ge
- Qishu Wu
- Ruochen Liu (ORCID: https://orcid.org/0000-0003-1061-1801)
Institutions
- Southwest University (CN)
- Chongqing University (CN)
- Guangxi Medical University (CN)
- Chongqing University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13046-024-03260-z
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Natural Science Foundation of Chongqing