Abdominal obesity and frailty progression in population across different Cardiovascular-Kidney-Metabolic syndrome stages: a nationwide longitudinal study
Abdominal obesity, indicated by BRI, is a strong predictor of frailty progression, particularly in early CKM stages. High cumulative BRI, along with advanced CKM progression and persistent advanced CKM stages, further increases frailty risk. Notably, BRI outperforms BMI in enhancing conventional frailty prediction models. These findings underscore the importance of monitoring abdominal obesity in early CKM stages to mitigate future frailty risk.
Authors
- Weiru Liang (ORCID: https://orcid.org/0000-0001-5919-9147)
- Cuijun Hao
- Meng Ning (ORCID: https://orcid.org/0000-0003-3883-7079)
- Chong Zhang (ORCID: https://orcid.org/0000-0001-9867-4190)
- Kun Hu (ORCID: https://orcid.org/0009-0009-0378-4369)
- Yi‐Ping Phoebe Chen (ORCID: https://orcid.org/0000-0002-4122-3767)
- Tingting Guo (ORCID: https://orcid.org/0009-0009-2547-0256)
- Yingwu Liu (ORCID: https://orcid.org/0000-0002-9500-9491)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Third Central Hospital (CN)
- Cell Technology (China) (HK)
- Tianjin Fire Research Institute (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s13098-025-01649-0
- Citations
- 8
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 9.79