Exploring the link between M1 macrophages and EMT of amniotic epithelial cells: implications for premature rupture of membranes
Inflammatory stimulation prompts the polarization of macrophages in amniotic fluid into the M1 type, which subsequently secrete EVs laden with inflammatory miRNAs. These EVs trigger the EMT of AECs, causing the loss of their epithelial phenotype. Consequently, the biomechanical properties of the amnion deteriorate, ultimately leading to its rupture, posing risks relevant to pregnancy complications such as premature rupture of membranes. The results of this study provide insights into the pathogenesis of PROM and will aid in treatment development.
Authors
- Yize Liu (ORCID: https://orcid.org/0000-0003-1348-1520)
- Xiangchen Li (ORCID: https://orcid.org/0000-0002-1812-2343)
- Jingmiao Zhang (ORCID: https://orcid.org/0000-0003-1080-9762)
- Jin H. Song (ORCID: https://orcid.org/0000-0002-0123-2909)
- Chunyu Bai (ORCID: https://orcid.org/0000-0002-2979-6060)
- Ningning Mi (ORCID: https://orcid.org/0000-0003-1752-185X)
- Miao Wang (ORCID: https://orcid.org/0000-0002-0532-6312)
- Zhikun Li (ORCID: https://orcid.org/0000-0003-2860-3965)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-8472-1136)
- Weijun Guan (ORCID: https://orcid.org/0000-0002-2203-7299)
- Yuhua Gao (ORCID: https://orcid.org/0000-0002-9332-1596)
Institutions
- Zhejiang A & F University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12951-025-03192-6
- Citations
- 5
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Natural Science Foundation of China