Impact of dual active ingredients long-lasting insecticidal nets on the genetic structure of insecticide resistant populations of Anopheles gambiae in Southern Benin
The frequency of the L1014F vgsc-kdr resistance allele was high, while that of the G119S-ace-1 allele was low throughout the study period. Consistent changes in allele frequencies were not observed in any of the treatment arms suggesting that the pyrethroid component of dual AI (active ingredients) nets continues to select for the resistant allele and there is little if any evidence that the non-pyrethroid insecticide selects for the wild-type kdr allele.
Authors
- Roseric Azondékon (ORCID: https://orcid.org/0000-0001-9155-4153)
- Albert Sourou Salako (ORCID: https://orcid.org/0000-0002-8177-3704)
- Jackie Cook (ORCID: https://orcid.org/0000-0002-3814-3467)
- Natacha Protopopoff (ORCID: https://orcid.org/0000-0001-6698-4936)
- Côme Z. Koukpo
- Manfred Accrombessi (ORCID: https://orcid.org/0000-0001-9550-9413)
- Edouard Dangbénon
- Arsène Fassinou
- Landry Assongba (ORCID: https://orcid.org/0000-0003-4092-2280)
- Clément Agbangla (ORCID: https://orcid.org/0000-0002-8783-0634)
- Antoine Abel Missihoun (ORCID: https://orcid.org/0000-0003-4381-922X)
- Fiacre Agossa (ORCID: https://orcid.org/0000-0002-0763-6007)
- Boulais Yovogan (ORCID: https://orcid.org/0009-0002-3088-7223)
- Germain Gil Padonou (ORCID: https://orcid.org/0000-0002-3802-6439)
- Idelphonse Ahogni
- Corine Ngufor (ORCID: https://orcid.org/0000-0002-7755-9609)
- Louisa A. Messenger (ORCID: https://orcid.org/0000-0002-3107-6214)
- Arthur Sovi
- Benoît Sessinou Assogba (ORCID: https://orcid.org/0000-0003-1677-2067)
- Esdras Mahoutin Odjo (ORCID: https://orcid.org/0009-0000-1437-5258)
- Constantin Adoha (ORCID: https://orcid.org/0000-0003-0079-8502)
- Armel Djènontin (ORCID: https://orcid.org/0000-0001-9595-2220)
- Serge Akpodji
- Martin Akogbéto
Institutions
- University of Nevada, Las Vegas (US)
- London School of Hygiene & Tropical Medicine (GB)
- Université de Parakou (BJ)
- MRC Unit the Gambia (GM)
- Université d'Abomey-Calavi (BJ)
- Medical Research Council (GB)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12936-025-05308-7
- Citations
- 3
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 5.64