Antibody correlates of risk of clinical malaria in an area of low and unstable malaria transmission in western Kenya
Antibody correlates of protection against clinical malaria were observed only in children < 5 years old in this area of low and unstable malaria transmission. In older children and adults in this area, some antibody responses correlated with increased risk of clinical malaria. Future studies in low malaria transmission areas should evaluate the comparative contributions of cellular and humoral immunity to protection from clinical malaria in young children versus older children and adults.
Authors
- Karen E. S. Hamre
- Bartholomew N. Ondigo (ORCID: https://orcid.org/0000-0003-3607-9964)
- David L. Narum (ORCID: https://orcid.org/0000-0003-3041-5402)
- George Ayodo (ORCID: https://orcid.org/0000-0002-5565-2415)
- D. Herbert Opi (ORCID: https://orcid.org/0000-0002-4589-4365)
- James G. Beeson (ORCID: https://orcid.org/0000-0002-1018-7898)
- Kagan A. Mellencamp (ORCID: https://orcid.org/0000-0003-3994-3869)
- Eliud O. Odhiambo
- Chandy C. John
Institutions
- Carter Center (US)
- National Institutes of Health (US)
- Burnet Institute (AU)
- Egerton University (KE)
- Jaramogi Oginga Odinga University of Science and Technology (KE)
- National Institute of Allergy and Infectious Diseases (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1186/s12936-025-05300-1
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88