Primary Vaginal Malignant Melanoma, Rare Form of Malignant Melanoma - A Case Report

Malignant Melanoma is a tumor of melanin producing cells called melanocytes. Vulvovaginal melanomas represent a unique subset of malignant melanoma, with reported incidence of 0.026/100 000 women per year. We present a case of 68 years post-menopausal lady who presented with mass per vagina. On examination there was 4*3 cms bluish-black colored polypoid growth arising from antero-lateral wall of vagina on right side in the lower third, and bleed on touch. Excisional biopsy was done under anesthesia. Histopathological findings showed large pleomorphic high-grade epithelioid melanocytic cells, confirming malignant melanoma. The malignant cells showed diffuse staining for S-100, HMB-45, Melan-A and focal weak positivity for SOX-10. Vulvovaginal melanomas are aggressive tumors with poor prognosis. They pose significant diagnostic and therapeutic challenges, underscoring the importance of early detection and intervention. Increased awareness and understanding of vulvovaginal melanomas can lead to earlier diagnosis and better management strategies, ultimately improving the survival rates.