The Utility of Synthetic Biology in the Treatment of Industrial Wastewaters

Effective treatment of industrial wastewater effluents before discharging them to the soil and water bodies has always been one of the paramount environmental concerns. The pollutants in untreated wastewater effluents have hazardous implications for human health and the ecosystem. Conventional physical and chemical processes of industrial wastewater treatment have many complications and they often fall short in the treatment of new and diverse varieties of pollutants. Several microbial strains in nature have shown their remediation property, but they possess limited efficiency in breaking down pollutants into non-toxic components. Synthetic biology is a perfect amalgam of two fields – biological science and engineering, and it has transformed our ways of understanding the functioning of complex biological systems. Researchers have reported that some engineered microbes can achieve remediation efficiency of up to 100% in specific pollutants such as heavy metals and hydrocarbons. For example, microbes like Pseudomonas veronii have been shown to reduce cadmium concentrations by up to 100%, and Pseudomonas putida has been shown to reduce phenol concentrations by 92%. Synthetic biology-based biosensors are also being developed for pollution monitoring and control of industrial wastewater. In this review, we discuss these advancements of synthetically engineered microorganisms in the treatment of industrial wastewater.