Demographics, epidemiology, mortality and difficult-to-treat resistance patterns of bacterial bloodstream infections in the global US Military Health System from 2010 to 2019: a retrospective cohort study

In the global US MHS, the mortality burden associated with BSI was substantial (approximately one in four dying at 1 year), relatively unchanged over a decade, and associated with older age and comorbidities. First-line treatment options remained available for 99.7% of BSIs. Population-level improvements in BSI survival might be maximally influenced by focusing on prevention, early detection, prompt antibiotics and other novel therapies not contingent on in vitro activity.

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Publication Details

Journal
BMJ Open
Published
2025-03-01
DOI
https://doi.org/10.1136/bmjopen-2024-094861
Citations
1
Primary Topic
Antibiotic Use and Resistance
Type
article
Field-Weighted Citation Impact
1.26

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article

Demographics, epidemiology, mortality and difficult-to-treat resistance patterns of bacterial bloodstream infections in the global US Military Health System from 2010 to 2019: a retrospective cohort study

Alexander Vostal, Katrin Mende, M Leigh Carson, Sarah Warner et al.
1 citations
BMJ Open
Antibiotic Use and Resistance
1.26
article

Demographics, epidemiology, mortality and difficult-to-treat resistance patterns of bacterial bloodstream infections in the global US Military Health System from 2010 to 2019: a retrospective cohort study

Alexander Vostal, Katrin Mende, M Leigh Carson, Sarah Warner, Dean Follmann, Nicholas Seliga, Edward Parmelee, Charlotte Lanteri, Carlos Morales, John H. Powers, Beth Poitras, Sameer S. Kadri, Melissa Grance, Jing Wang, Uzo Chukwuma
article en
1 citations

Abstract

In the global US MHS, the mortality burden associated with BSI was substantial (approximately one in four dying at 1 year), relatively unchanged over a decade, and associated with older age and comorbidities. First-line treatment options remained available for 99.7% of BSIs. Population-level improvements in BSI survival might be maximally influenced by focusing on prevention, early detection, prompt antibiotics and other novel therapies not contingent on in vitro activity.

BMJ OpenVol. 15(3)
Henry M. Jackson Foundation (US), Brooke Army Medical Center (US), National Institutes of Health (US), Uniformed Services University of the Health Sciences (US), Indian Health Service (US), National Heart, Lung, and Blood Institute (US), Navy and Marine Corps Force Health Protection Command (US), Frederick National Laboratory for Cancer Research (US), National Institute of Allergy and Infectious Diseases (US), National Cancer Institute (US), National Institutes of Health Clinical Center (US), Joint Base San Antonio (US)
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institute of Allergy and Infectious Diseases
Good health and well-being
Openalex Percentile: Top 21%
Antibiotic Use and Resistance
1.26
DOIOpen Access PDFOpenAlex
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