Integrated clinico-molecular analysis of gastric cancer in European and Latin American populations: LEGACY project
Our findings relate specific molecular alterations of GC tumors from Europe and LATAM to actionable biomarkers for precision cancer therapies. The proposed GC stratification can be implemented in routine care and guide drug development strategies.
Authors
- Carmela Caballero (ORCID: https://orcid.org/0000-0002-3586-6598)
- Angélica Hernández-Guerrero (ORCID: https://orcid.org/0000-0002-6957-3531)
- Manuel Cabeza-Segura (ORCID: https://orcid.org/0000-0002-3257-1292)
- Erika Ruíz‐García (ORCID: https://orcid.org/0000-0002-0446-123X)
- Berenice Freile (ORCID: https://orcid.org/0000-0003-3192-126X)
- Juan Manuel O’Connor (ORCID: https://orcid.org/0000-0002-6975-5466)
- Rita Barros (ORCID: https://orcid.org/0000-0002-1667-7329)
- Cinthia Gauna (ORCID: https://orcid.org/0009-0001-5669-8431)
- Gareth I. Owen (ORCID: https://orcid.org/0000-0003-3807-6054)
- Judit Matito (ORCID: https://orcid.org/0000-0001-7560-7737)
- M. Gómez-González (ORCID: https://orcid.org/0000-0002-1960-6083)
- Sarah Derks (ORCID: https://orcid.org/0000-0002-4547-7457)
- María Alsina (ORCID: https://orcid.org/0000-0003-4835-7159)
- Maria del Mar Vila
- Fátima Carneiro (ORCID: https://orcid.org/0000-0002-1964-1006)
- Roos E. Pouw (ORCID: https://orcid.org/0000-0002-4707-1186)
- Elena Jiménez-Martí (ORCID: https://orcid.org/0000-0002-1537-5337)
- Ricardo Pereira (ORCID: https://orcid.org/0000-0001-6672-5395)
- Edith A. Fernández-Figueroa (ORCID: https://orcid.org/0000-0002-5159-8300)
- Hugo Boggino (ORCID: https://orcid.org/0009-0002-7615-7023)
- Andreia Costa (ORCID: https://orcid.org/0000-0002-5331-9934)
- Horacio Lezcano
- Rui M. Ferreira (ORCID: https://orcid.org/0000-0003-0961-2356)
- Roberto Herrera‐Goepfert (ORCID: https://orcid.org/0000-0001-7901-2378)
- Luis Caro
- Florian Lordick (ORCID: https://orcid.org/0000-0001-8591-9339)
- Tania Fleitas (ORCID: https://orcid.org/0000-0002-2789-9082)
- Juan Carlos Roa (ORCID: https://orcid.org/0000-0001-8313-8774)
- Federico Esteso (ORCID: https://orcid.org/0000-0003-1977-9846)
- Céu Figueiredo (ORCID: https://orcid.org/0000-0001-5247-840X)
- A. Miralles
- Alberto M. León-Takahashi (ORCID: https://orcid.org/0000-0001-8031-8358)
- Melissa Mendes-Rocha
- Leonardo Saul Lino-Silva (ORCID: https://orcid.org/0000-0002-7394-5123)
- Rosana Villagrasa
- Marcelo Garrido (ORCID: https://orcid.org/0000-0001-8905-8986)
- Erick Riquelme (ORCID: https://orcid.org/0000-0002-2696-7995)
- Judith Farrés (ORCID: https://orcid.org/0000-0002-0958-0510)
- Ana P. Vivancos (ORCID: https://orcid.org/0000-0003-2888-6512)
- Carlos Dı́az Romero (ORCID: https://orcid.org/0000-0001-8314-4584)
- Ágatha Martín (ORCID: https://orcid.org/0000-0003-4818-6433)
- L. Alarcón-Molero
- João Santos‐Antunes (ORCID: https://orcid.org/0000-0003-0614-0576)
- Fiorella Ruíz‐Pace (ORCID: https://orcid.org/0000-0002-3932-0170)
- Daniel Cantero
- Arnoldo J. Riquelme (ORCID: https://orcid.org/0000-0002-8259-8960)
- Carolina Martínez‐Ciarpaglini (ORCID: https://orcid.org/0000-0002-8797-2114)
- Tessa S. Groen-van Schooten (ORCID: https://orcid.org/0009-0004-7749-929X)
- Nadia Melissa Valdez-Reyes
- Juan Carlos Falcón-Martínez
- Sergio Romero (ORCID: https://orcid.org/0000-0001-7379-7434)
- E. Castillo (ORCID: https://orcid.org/0000-0001-8424-4077)
- Marc Diez‐García
- Rodrigo Dienstmann
- A. Cervantes
- Gonzalo Latorre (ORCID: https://orcid.org/0009-0000-2311-8747)
Institutions
- Twitter (United States) (US)
- Universidad Mayor (CL)
- Universitat de València (ES)
- Pontificia Universidad Católica de Chile (CL)
- Universidade do Porto (PT)
- Hospital Clínico Universitario de Valencia (ES)
- Gastroenterología Diagnóstica Terapeútica (AR)
- Amsterdam Neuroscience (NL)
- National Institute of Genomic Medicine (MX)
- Navarrabiomed (ES)
- Guyra Paraguay (PY)
- Instituto Alexander Fleming (AR)
- Hospital General Universitario De Valencia (ES)
- Amsterdam University Medical Centers (NL)
- Instituto Nacional de Cancerología (MX)
- INCLIVA Health Research Institute (ES)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Millennium Institute on Immunology and Immunotherapy (CL)
- Anaxomics (Spain) (ES)
- IPS Central (PY)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104482
- Citations
- 3
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Jazz Pharmaceuticals
- Institut Català de Nanociència i Nanotecnologia
- BeiGene
- Ribon Therapeutics
- Natera
- European Commission
- Daiichi-Sankyo
- Astellas Pharma
- European Society for Medical Oncology
- Servier
- Ipsen
- Agencia Nacional de Investigación y Desarrollo
- Genentech
- Foundation Medicine
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias
- Daiichi Sankyo Europe