Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study
Among patients with pre-existing cardiac metastasis, ICIs demonstrated meaningful clinical efficacy with no increase in safety signals. Most patients had concordant responses in the overall disease burden and cardiac mass. Multidisciplinary teams are crucial for the appropriate management of patients with cardiac metastasis.
Authors
- Elias Bou Farhat (ORCID: https://orcid.org/0009-0001-0063-0518)
- Noha Abdel‐Wahab (ORCID: https://orcid.org/0000-0002-7621-9266)
- David James Pinato (ORCID: https://orcid.org/0000-0002-3529-0103)
- Nerea Lopetegui‐Lia (ORCID: https://orcid.org/0000-0002-6207-2371)
- Sarah Abou Alaiwi (ORCID: https://orcid.org/0000-0002-7073-3432)
- Jonathan C. Trent (ORCID: https://orcid.org/0000-0001-6169-5238)
- Ryan Denu
- Ahmad Al‐Hader
- Walid Macaron (ORCID: https://orcid.org/0000-0001-5168-0163)
- Jesús Antonio Ocejo Gallegos (ORCID: https://orcid.org/0000-0002-0664-2376)
- Douglas Buckner Johnson (ORCID: https://orcid.org/0000-0002-6390-773X)
- Edward El‐Am (ORCID: https://orcid.org/0000-0002-1105-9310)
- Shirly Grynberg (ORCID: https://orcid.org/0000-0003-0562-2100)
- Talal El Zarif (ORCID: https://orcid.org/0000-0002-4507-2396)
- Gavin Hui (ORCID: https://orcid.org/0000-0002-4818-4254)
- N. Jones (ORCID: https://orcid.org/0000-0001-8510-8827)
- Alexandra Drakaki
- Igor Stukalin (ORCID: https://orcid.org/0000-0002-0943-8637)
- Vishal Navani (ORCID: https://orcid.org/0000-0002-6795-009X)
- Rachel Woodford (ORCID: https://orcid.org/0000-0002-9470-314X)
- Jennifer M. Kwan (ORCID: https://orcid.org/0000-0002-4715-1848)
- Susan Dent (ORCID: https://orcid.org/0000-0002-9183-9340)
- Dory Freeman (ORCID: https://orcid.org/0000-0003-2617-0641)
- Mingjia Li (ORCID: https://orcid.org/0000-0002-3910-4179)
- Tarek Haykal (ORCID: https://orcid.org/0000-0002-8637-7292)
- Arjun Mittra (ORCID: https://orcid.org/0000-0001-9572-3495)
- Toni K. Choueiri (ORCID: https://orcid.org/0000-0002-9201-3217)
- Ankita Tandon (ORCID: https://orcid.org/0000-0002-7527-0772)
- Élizabeth Anderson (ORCID: https://orcid.org/0000-0001-6652-1544)
- Pauline Funchain (ORCID: https://orcid.org/0000-0002-7568-8626)
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Alessio Cortellini (ORCID: https://orcid.org/0000-0002-1209-5735)
- Kaushal Parikh (ORCID: https://orcid.org/0000-0002-3247-3676)
- Elie Kozaily (ORCID: https://orcid.org/0000-0002-6719-0422)
- Javier Baena Preysler (ORCID: https://orcid.org/0000-0002-6373-8286)
- Georgina Venetia Long (ORCID: https://orcid.org/0000-0001-8894-3545)
- Daniel E. Meyers (ORCID: https://orcid.org/0000-0002-7619-7327)
- Alexi L. Vasbinder (ORCID: https://orcid.org/0000-0002-1380-5364)
- Eric H. Yang (ORCID: https://orcid.org/0000-0003-4889-7454)
- Aakash Desai (ORCID: https://orcid.org/0000-0002-2943-3817)
- Alexandra Trevino
- Paul Sackstein (ORCID: https://orcid.org/0000-0003-3786-6126)
- Carmel Malvar
- Frank Aboubakar Nana
- Simone Foderaro (ORCID: https://orcid.org/0000-0001-5864-0180)
- Tomas G. Neilan (ORCID: https://orcid.org/0000-0002-1513-8833)
- James Korolewicz (ORCID: https://orcid.org/0000-0002-8006-5466)
- Aarti H. Asnani (ORCID: https://orcid.org/0000-0003-4967-9918)
- Caleb J. Smith (ORCID: https://orcid.org/0000-0003-1974-0175)
- Nausheen Akhter (ORCID: https://orcid.org/0000-0001-9423-8578)
- Abdul Rafeh Naqash (ORCID: https://orcid.org/0000-0001-7622-720X)
- Chul Kim (ORCID: https://orcid.org/0000-0003-0191-8684)
- Sanober Nusrat (ORCID: https://orcid.org/0000-0003-2261-2713)
- Yuki Kojima
- Rachel Goodman (ORCID: https://orcid.org/0000-0001-7992-8108)
- P. Narendra Babu
- Arrush Choudhary
- M. Herrera
- Ronnie Shapira
- Kan Yonemor
- Salim Hayeck
Institutions
- Northwestern University (US)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Brigham and Women's Hospital (US)
- The University of Sydney (AU)
- Loyola University Medical Center (US)
- Cliniques Universitaires Saint-Luc (BE)
- Beth Israel Deaconess Medical Center (US)
- Cleveland Clinic (US)
- Mayo Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Miami (US)
- Università Campus Bio-Medico (IT)
- University of California, Los Angeles (US)
- University of Calgary (CA)
- Duke University (US)
- Georgetown University (US)
- Sheba Medical Center (IL)
- Hammersmith Hospital (GB)
- WinnMed (US)
- MedStar Georgetown University Hospital (US)
- Yale University (US)
- University of California San Diego (US)
- Research Institute Hospital 12 de Octubre (ES)
- Massachusetts General Hospital (US)
- Michigan Medicine (US)
- Dana-Farber Cancer Institute (US)
- Melanoma Institute Australia (AU)
- Eskenazi Health Foundation (US)
- Oklahoma State University Oklahoma City (US)
- Campus Bio Medico University Hospital (IT)
- Tokyo National Hospital (JP)
- Imperial College London (GB)
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Oklahoma (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-009364
- Citations
- 5
- Primary Topic
- Cardiac tumors and thrombi
- Type
- article
- Field-Weighted Citation Impact
- 6.94