Associations of DNA methylation in breast tumour subtypes with parity and breastfeeding in a cohort of 1459 Black women: implications for public health
In this large study of Black women with breast cancer, we elucidated biological pathways for the observed associations between parity without breastfeeding and breast cancer subtypes, revealing distinct molecular alterations in breast DNA, particularly for ER- tumours. Black women in the USA tend to have more children and are less likely to breastfeed; their breast cancer risk may be reduced by societal systems that promote and support breastfeeding.
Authors
- Warren Davis (ORCID: https://orcid.org/0000-0002-8700-5693)
- Elisa V. Bandera (ORCID: https://orcid.org/0000-0002-8789-2755)
- Zhihong Gong (ORCID: https://orcid.org/0000-0003-1129-1774)
- Mark D. Long (ORCID: https://orcid.org/0000-0003-1120-8176)
- Song Yao (ORCID: https://orcid.org/0000-0001-9442-1313)
- Lawrence H. Kushi (ORCID: https://orcid.org/0000-0001-9136-1175)
- Christine B. Ambrosone (ORCID: https://orcid.org/0000-0003-1717-9943)
- Qiang Hu (ORCID: https://orcid.org/0000-0002-4090-5539)
- Gary Zirpoli (ORCID: https://orcid.org/0000-0003-1417-5349)
- Thaer Khoury (ORCID: https://orcid.org/0000-0002-8112-6590)
- Sirinapa Szewczyk
- Rochelle Payne Ondracek (ORCID: https://orcid.org/0000-0002-4085-3054)
- Angela R. Omilian (ORCID: https://orcid.org/0000-0001-6348-9411)
- Julie R. Palmer (ORCID: https://orcid.org/0000-0002-6534-335X)
- Song Liu (ORCID: https://orcid.org/0000-0001-6351-2941)
- Chunyu Liu (ORCID: https://orcid.org/0000-0002-5986-4415)
- Jianhong Chen (ORCID: https://orcid.org/0000-0001-7229-1853)
- Michael J. Higgins (ORCID: https://orcid.org/0000-0002-3571-018X)
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- Roswell Park Comprehensive Cancer Center (US)
- Kaiser Permanente (US)
Publication Details
- Journal
- BMJ Oncology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/bmjonc-2024-000675
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Breast Cancer Research Foundation
- National Cancer Institute