Association between stroke and systemic inflammation response index (SIRI): a National Health and Nutrition Examination Survey (NHANES) Study 2015–2020

This study revealed that among the hsCRP, IBI, NLR and SIRI, SIRI is the only one independently associated with a history of stroke. Our findings, in conjunction with the pre-existing evidence from observational and experimental studies, highlight the role of monocytes as a component of SIRI in chronic inflammation, which may induce vascular thrombotic events, including stroke.