Delivery of Polypeptide Drugs Using Nanoparticles Made of Recombinant Spider Silks Derived From MaSp4 Protein
We developed three recombinant silk proteins, M4R2, M4R4, and M4R6, demonstrating that M4R2 particles, with stable colloidal properties, high loading efficiency of positively charged drugs, and controlled release rates, are promising new particulate drug carrier systems for the delivery of polypeptided drugs.
Authors
- Rui Wen (ORCID: https://orcid.org/0000-0003-2644-7452)
- Peng Zheng (ORCID: https://orcid.org/0000-0001-5907-8505)
Institutions
- Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/ijn.s510273
- Citations
- 3
- Primary Topic
- Silk-based biomaterials and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.79