SCGB1A1 as a Key Regulator of Splenic Immune Dysfunction in COPD: Insights From a Murine Model
These findings suggest that SCGB1A1 contributes to splenic immune dysfunction in COPD. Targeted inhibition of SCGB1A1 expression in the spleen may represent a potential therapeutic strategy to reduce the risk of sepsis in COPD patients.
Authors
- Jianting Shi (ORCID: https://orcid.org/0000-0003-1558-7791)
- Shanping Jiang (ORCID: https://orcid.org/0000-0002-6222-0282)
- Xinye Chen (ORCID: https://orcid.org/0000-0003-1778-393X)
- Yanru Wu (ORCID: https://orcid.org/0000-0002-1447-5336)
- Fengzhan Ye (ORCID: https://orcid.org/0009-0001-3852-1704)
- Linjie Huang (ORCID: https://orcid.org/0000-0001-5660-7360)
- Xiaoping Huang (ORCID: https://orcid.org/0000-0002-6826-0322)
- Qiujie Wang (ORCID: https://orcid.org/0000-0003-4942-8166)
- Mengyan Gong (ORCID: https://orcid.org/0000-0003-2504-8724)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/copd.s506332
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59