Brain Ischemia in Alzheimer’s Disease May Partly Counteract the Disruption of the Blood–Brain Barrier
A hypothesis is put forward that the BBB disruption in AD is partially mitigated by the brain making itself ischemic. Modelling gives support to this hypothesis. The model can suggest a cause for the development of ischemic neuronal loss and amyloid accumulation secondary to glymphatic flow disruption as AD progresses.
Authors
- Alexander Robert Bateman (ORCID: https://orcid.org/0000-0001-6090-5344)
- Grant A. Bateman (ORCID: https://orcid.org/0000-0003-3095-9047)
Institutions
- John Hunter Hospital (AU)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-03-02
- DOI
- https://doi.org/10.3390/brainsci15030269
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 1.82