Analysis of proinflammatory cytokine responses in Takayasu arteritis
This study supports cell-mediated cytotoxicity as the main pathogenetic mechanism of TAK. T cells express higher levels of IFN-γ in TAK but not IL-17. Supernatant analysis indicated significantly higher IFN-γ production, which significantly increased after induction, suggesting the contribution of different inflammatory cells (probably CD8<sup>+</sup> and γδ<sup>+</sup> T cells) to IFN-γ production in TAK.
Authors
- Fatma Alıbaz-Öner (ORCID: https://orcid.org/0000-0002-6653-1758)
- Haner Di̇reskeneli̇ (ORCID: https://orcid.org/0000-0003-2598-5806)
- Aysın Tulunay Virlan (ORCID: https://orcid.org/0000-0003-4735-9902)
- imren aydın (ORCID: https://orcid.org/0000-0001-7389-4576)
- Gülşen Özen (ORCID: https://orcid.org/0000-0002-5423-393X)
- Filiz Türe Özdemir (ORCID: https://orcid.org/0000-0001-6144-5220)
- Rabia Deniz (ORCID: https://orcid.org/0000-0003-4537-894X)
- Ali Ugur Unal (ORCID: https://orcid.org/0000-0002-4682-537X)
Institutions
- Sağlık Bilimleri Üniversitesi (TR)
- Marmara University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Archives of Rheumatology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.46497/archrheumatol.2024.10790
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00