Baseline Functional Connectivity of the Mesolimbic, Salience, and Sensorimotor Systems Predicts Responses to Psychological Therapies for Chronic Low Back Pain With Comorbid Depression: A Functional MRI Study
We illustrate the potential of FC as a biomarker of CLBP plus depression and the response to CBT. Our data suggest ACT and BATD have differing underlying brain mechanisms. These findings indicate that FC biomarkers could guide personalized treatment, improving individual outcomes.
Authors
- Carlos G. Forero (ORCID: https://orcid.org/0000-0002-5245-0076)
- Sonia Medina (ORCID: https://orcid.org/0000-0001-8883-6520)
- Jaime Navarrete (ORCID: https://orcid.org/0000-0002-9482-4822)
- Owen O’Daly (ORCID: https://orcid.org/0000-0001-5690-1252)
- Juan V. Luciano (ORCID: https://orcid.org/0000-0003-0750-1599)
- Juan P. Sanabria‐Mazo (ORCID: https://orcid.org/0000-0003-1688-435X)
- Carla Rodríguez‐Freire (ORCID: https://orcid.org/0009-0006-6728-5778)
- Matthew A. Howard (ORCID: https://orcid.org/0000-0002-9359-3057)
Institutions
- Universitat Autònoma de Barcelona (ES)
- King's College London (GB)
- University of Exeter (GB)
- Universitat Internacional de Catalunya (ES)
- Parc Sanitari Sant Joan de Déu (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1002/brb3.70380
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- European Commission
- Medical Research Council
- Instituto de Salud Carlos III
- European Regional Development Fund