Decreased Endogenous Nitric Oxide Production in Acute Decompensated Heart Failure with a Reduced Ejection Fraction
We present novel data with regard to plasma NO<sub>2</sub> <sup>-</sup> in both acute and chronic HFrEF. Our results indicate that patients with acute HFrEF have a relative deficiency of plasma NO<sub>2</sub> <sup>-</sup> whilst also displaying a relative increase in ADMA, a modulator of eNOS. Reduced NO bioavailability may therefore relate to impaired NO production in patients with acute decompensation, with implications for both treatment and prevention of episodes.
Authors
- Sara Vogrin (ORCID: https://orcid.org/0000-0002-1597-9421)
- Roman Falls (ORCID: https://orcid.org/0000-0001-9562-194X)
- Bing H. Wang (ORCID: https://orcid.org/0000-0001-9580-2548)
- Christopher Neil (ORCID: https://orcid.org/0000-0002-1546-4022)
Institutions
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- Western Health (AU)
- RMIT University (AU)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ehf2.15253
- Citations
- 2
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 4.76