Regulatory T‐Cells During Pregnancy Relate to Women's Own Childhood History of Microbial Exposure
These findings offer insights that may help elucidate the relative contributions of early-life pathogenic ("hygiene hypothesis") and benign ("old friends hypothesis") microbial exposures toward the expansion of the Treg compartment. Human evolutionary history is characterized by changing microbial exposures as human residency patterns, living environments, and subsistence strategies changed. In this context, our findings suggest the possibility of less gestational pathology in human evolutionary past conditions typified by richer diversity of microbial exposure.
Authors
- Kyle S. Wiley (ORCID: https://orcid.org/0000-0003-0233-9561)
- Dayoon Kwon (ORCID: https://orcid.org/0000-0001-7967-8508)
- Delaney A. Knorr (ORCID: https://orcid.org/0000-0002-5105-8742)
- Adiba Hassan (ORCID: https://orcid.org/0000-0002-7622-7709)
- Molly Fox (ORCID: https://orcid.org/0000-0001-9219-8971)
Institutions
- University of California, Los Angeles (US)
- The University of Texas at El Paso (US)
- Duke University (US)
- UCLA Health (US)
Publication Details
- Journal
- American Journal of Human Biology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1002/ajhb.70013
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases
- Institute of American Cultures, University of California, Los Angeles
- National Institute on Minority Health and Health Disparities
- Clinical and Translational Science Institute, University of California, Los Angeles