Tranexamic acid is associated with post‐injury mortality in a resource‐limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study

Early TXA administration significantly reduced mortality in trauma patients, especially with penetrating injuries and those with the highest risk of hemorrhage. One-gram dosing was as effective as higher doses, and mortality reduction was notable when TXA was given within 2 h post-injury. These findings support TXA use in resource-limited trauma protocols.

Authors

Hendrick J. Lategan
Willem Stassen (ORCID: https://orcid.org/0000-0002-1486-4446)
Elmin Steyn (ORCID: https://orcid.org/0000-0002-8090-1559)
Denise Lourens
Lesley Hodsdon
Julia Dixon (ORCID: https://orcid.org/0000-0002-9229-2658)
Mohammed Mayet (ORCID: https://orcid.org/0000-0001-5155-9427)
Ernest Eugene Moore (ORCID: https://orcid.org/0000-0002-0419-4848)
Janette Verster (ORCID: https://orcid.org/0000-0002-1273-5456)
Karlien Doubell
Craig Wylie (ORCID: https://orcid.org/0000-0003-2168-4838)
Smitha Bhaumik (ORCID: https://orcid.org/0000-0002-2981-9293)
Christiaan A. Rees (ORCID: https://orcid.org/0000-0003-1896-5348)
Nee‐Kofi Mould‐Millman (ORCID: https://orcid.org/0000-0003-4303-6903)
Steven Gremel Schauer (ORCID: https://orcid.org/0000-0002-2322-5216)
Adane F. Wogu (ORCID: https://orcid.org/0000-0002-6592-6512)
Jessica L Young (ORCID: https://orcid.org/0000-0002-5619-5113)
Shaheem de Vries (ORCID: https://orcid.org/0000-0003-3986-1652)
L’Oreal Snyders
Leigh Wagner
Mengli Xiao (ORCID: https://orcid.org/0000-0003-4974-3588)
George Oosthuizen

Institutions

Western Cape Department of Health (ZA)
Colorado School of Public Health (US)
University of Cape Town (ZA)
Stellenbosch University (ZA)
Denver Health Medical Center (US)
Health and Hospital Corporation (US)
Right to Care (ZA)
University of Colorado Anschutz Medical Campus (US)
University of Colorado Denver (US)

Publication Details

Journal: Transfusion
Published: 2025-02-28
DOI: https://doi.org/10.1111/trf.18171
Citations: 2
Primary Topic: Trauma, Hemostasis, Coagulopathy, Resuscitation
Type: article
Field-Weighted Citation Impact: 3.09

Funders

U.S. Department of Defense

Tranexamic acid is associated with post‐injury mortality in a resource‐limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study

Hendrick J. Lategan, Willem Stassen, Elmin Steyn, Denise Lourens, Lesley Hodsdon, Julia Dixon, Mohammed Mayet, Ernest Eugene Moore, Janette Verster, Karlien Doubell, Craig Wylie, Smitha Bhaumik, Christiaan A. Rees, Nee‐Kofi Mould‐Millman, Steven Gremel Schauer, Adane F. Wogu, Jessica L Young, Shaheem de Vries, L’Oreal Snyders, Leigh Wagner, Mengli Xiao, George Oosthuizen

February 28, 2025article en

2 citations

Tranexamic acid is associated with post‐injury mortality in a resource‐limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study

Authors

Institutions

Publication Details

Funders

Tranexamic acid is associated with post‐injury mortality in a resource‐limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study

Tranexamic acid is associated with post‐injury mortality in a resource‐limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study

Abstract

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