Sex disparity in adult asthma—A potential immunomodulatory role of let‐7 family microRNAs
Our study demonstrates different inflammatory signatures between males and females with asthma. Let-7 miRNAs act as immune modulators by inhibiting the production of IL-13 and may be an important factor explaining the sex disparity seen in asthma.
Authors
- Madeleine Rådinger (ORCID: https://orcid.org/0000-0002-0652-7378)
- Emma Boberg
- Kristina Johansson (ORCID: https://orcid.org/0000-0001-7330-2665)
- Linda Ekerljung (ORCID: https://orcid.org/0000-0001-5784-0041)
- Hannu Kankaanranta (ORCID: https://orcid.org/0000-0001-5258-0906)
- Roxana Mincheva (ORCID: https://orcid.org/0000-0002-6072-2748)
- Henric Olsson (ORCID: https://orcid.org/0000-0002-5101-8871)
- Jenny Calvén
- Julie Weidner (ORCID: https://orcid.org/0000-0002-7140-8666)
- Christopher McCrae (ORCID: https://orcid.org/0000-0001-7184-9069)
- Patricia Ramos‐Ramírez (ORCID: https://orcid.org/0000-0001-5546-277X)
- Bright I. Nwaru (ORCID: https://orcid.org/0000-0002-2876-6089)
- Carina Malmhäll (ORCID: https://orcid.org/0000-0001-6696-7570)
Institutions
- Tampere University (FI)
- Seinäjoki University of Applied Sciences (FI)
- Karolinska Institutet (SE)
- AstraZeneca (Sweden) (SE)
- AstraZeneca (United States) (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical and Translational Allergy
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1002/clt2.70042
- Citations
- 3
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet