Prevalence of Constitutional Pathogenic Variant in a Cohort of 348 Patients With Multiple Primary Cancer Addressed in Oncogenetic Consultation
Patients referred for oncogenetic testing with MPM are more likely to carry pathogenic variants in cancer predisposition genes than patients with a single primary cancer (p < 0.05), especially if the cancers are related to the same predisposition syndrome. If the cancers are unrelated, no statistical difference in comparison to the single-cancer population was observed. For these latter patients, we recommend using the specific criteria of each tumor to propose appropriate genetic testing.
Authors
- Flora Ponelle‐Chachuat (ORCID: https://orcid.org/0000-0002-3637-5504)
- Mathilde Gay‐Bellile (ORCID: https://orcid.org/0000-0002-3059-532X)
- Yannick Bidet (ORCID: https://orcid.org/0000-0002-9624-8195)
- Mathias Cavaillé (ORCID: https://orcid.org/0000-0002-4079-4891)
- Nancy Uhrhammer (ORCID: https://orcid.org/0000-0002-7816-2398)
- Ioana Molnar (ORCID: https://orcid.org/0000-0001-5114-2648)
- Mathis Lepage
- Maud Privat
Institutions
- Inserm (FR)
- Université Clermont Auvergne (FR)
- Centre Jean Perrin (FR)
- Université Laval (CA)
Publication Details
- Journal
- Molecular Genetics & Genomic Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/mgg3.70086
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47