Seroprevalence of people vaccinated or not against COVID-19 in the city of Conakry

The coronavirus pandemic (COVID-19) is a potentially fatal disease that has caused a global public health crisis. Its treatment is symptomatic because until now the WHO has not approved an effective treatment against this disease. This is why today hope is turned to vaccination to curb this global pandemic. The presence of anti-SARSCoV-2 antibodies in the serum of sick (symptomatic or asymptomatic) and vaccinated individuals must be evaluated for the proper understanding of natural or adaptive immunity. We conducted a cross-sectional study of 6 months duration. The working methodology consisted in the determination of anti-SARSCoV-2 antibodies in the serum of unvaccinated (asymptomatic) and vaccinated persons by the Elisa method. We found 33.66% positive cases in unvaccinated persons and 93.51% positive cases in vaccinated persons. The most affected commune in both groups (vaccinated and non-vaccinated) was Ratoma with respectively 35% and 65%. There were 57.14% males in the unvaccinated group versus 64.98% in the unvaccinated group. The age group that developed the most antibodies in both study groups was 20-39 years old with 35% and 65% respectively. The optical density was higher in vaccinated persons than in unvaccinated persons. In sum, according to the results found in this study, we must remember that more antibodies are developed in the vaccinated population than in the non-vaccinated.