Cirsium japonicum leaf extract attenuated lipopolysaccharide-induced acute respiratory distress syndrome in mice via suppression of the NLRP3 and HIF1α pathways
CJE suppressed multiple inflammatory responses through the regulation of NLRP3 and HIF1α signaling-related gene expression in macrophages of LPS-induced ARDS mice. These results suggest that CJE has therapeutic potential for treating patients with ARDS via macrophage regulation.
Authors
- Hee Soon Shin (ORCID: https://orcid.org/0000-0002-0942-7161)
- Ji-Eun Eom
- Hyeon-Ji Song (ORCID: https://orcid.org/0009-0008-1515-4308)
- Eun Yeong Lim (ORCID: https://orcid.org/0000-0003-0910-6410)
- Ha‐Jung Kim (ORCID: https://orcid.org/0000-0002-2699-0263)
- Gun‐Dong Kim
- Dong‐Uk Shin
- Hyun‐Jin Kim (ORCID: https://orcid.org/0000-0002-7284-3547)
- So‐Young Lee (ORCID: https://orcid.org/0000-0002-5020-5982)
- Young In Kim (ORCID: https://orcid.org/0000-0001-7279-2519)
Institutions
- Gyeongsang National University (KR)
- Korea Food Research Institute (KR)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1016/j.phymed.2025.156601
- Citations
- 1
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 1.52