The “Wearing Off” Phenomenon for Rasagiline, Entacapone, Carbidopa, and Levodopa in the Setting of Parkinson’s Disease

This case highlights the importance of accurate dosage and vigilant supervision of Parkinson's disease medications' "wearing off" phenomenon. The patient's varying reaction to changes in medication and the subsequent appearance of psychiatric symptoms highlights the need for an individualized approach to managing Parkinson's disease. Collectively, these symptoms suggest that clinicians should consider the possibility of non-linear connections between dopaminergic therapy and symptom control. To effectively address the intricate relationship between motor symptoms and psychiatric manifestations, it is imperative to implement a multidisciplinary team approach in future management. This approach would involve closely monitoring and adapting treatment strategies.

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Publication Details

Journal
HCA Healthcare Journal of Medicine
Published
2025-02-28
DOI
https://doi.org/10.36518/2689-0216.1718
Citations
1
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
1.39
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article

The “Wearing Off” Phenomenon for Rasagiline, Entacapone, Carbidopa, and Levodopa in the Setting of Parkinson’s Disease

Terry Taewoong Um, R. L. Cromwell
1 citations
HCA Healthcare Journal of Medicine
Parkinson's Disease Mechanisms and Treatments
1.39
article

The “Wearing Off” Phenomenon for Rasagiline, Entacapone, Carbidopa, and Levodopa in the Setting of Parkinson’s Disease

Terry Taewoong Um, R. L. Cromwell
article en
1 citations

Abstract

This case highlights the importance of accurate dosage and vigilant supervision of Parkinson's disease medications' "wearing off" phenomenon. The patient's varying reaction to changes in medication and the subsequent appearance of psychiatric symptoms highlights the need for an individualized approach to managing Parkinson's disease. Collectively, these symptoms suggest that clinicians should consider the possibility of non-linear connections between dopaminergic therapy and symptom control. To effectively address the intricate relationship between motor symptoms and psychiatric manifestations, it is imperative to implement a multidisciplinary team approach in future management. This approach would involve closely monitoring and adapting treatment strategies.

HCA Healthcare Journal of MedicineVol. 6(1)
Florida Department of Citrus (US)
Openalex Percentile: Top 23%
Parkinson's Disease Mechanisms and Treatments
1.39
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The “Wearing Off” Phenomenon for Rasagiline, Entacapone, Carbidopa, and Levodopa in the Setting of Parkinson’s Disease — Terry Taewoong Um, R. L. Cromwell · HCA Healthcare Journal of Medicine (2025) | TGRS Research Map | TGRS