TMEM52B-derived peptides inhibit generation of soluble E-cadherin and EGFR activity to suppress colon cancer growth and early metastasis
These results strongly suggest that TMEM52B ECD-derived peptides could provide a platform for the development of novel anti-cancer therapeutics and furnish a useful tool for exploring the function of TMEM52B in modulating the interplay between E-cadherin and EGFR.
Authors
- Semi Kim (ORCID: https://orcid.org/0000-0001-8043-1465)
- Dongjoon Ko (ORCID: https://orcid.org/0000-0002-1474-7055)
- Yunhee Lee
- Junghwa Yoon
Institutions
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1186/s12967-025-06075-4
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Research Foundation of Korea