Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke
Our results suggest that ghrelin has a significant pro-neuroregenerative effect by enhancing long-term survival and sustained proliferation of neurons in the dentate gyrus and peri-infarct area, thus promoting functional recovery. Overall, ghrelin represents a promising target in the subacute and chronic phase after ischemic stroke.
Authors
- Elena Altach
- Heinz Wiendl (ORCID: https://orcid.org/0000-0003-4310-3432)
- Jan‐Kolja Strecker (ORCID: https://orcid.org/0000-0003-1518-6971)
- Kai Diederich (ORCID: https://orcid.org/0000-0002-6550-9460)
- Antje Schmidt‐Pogoda (ORCID: https://orcid.org/0000-0002-0389-6389)
- Ulrike Schreiner
- Carolin Beuker (ORCID: https://orcid.org/0000-0003-3495-0357)
- Jens Minnerup (ORCID: https://orcid.org/0000-0002-0382-5759)
- Verena Rätzel
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- University Hospital Münster (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Neurological Research and Practice
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1186/s42466-025-00371-6
- Citations
- 2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 1.83
Funders
- Westfälische Wilhelms-Universität Münster