Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis
Our findings expand the pharmacological properties of ICS II by demonstrating its ability to ameliorate PSD through modulation of the microbiota-gut-brain axis. ICS Ⅱ, as a novel Sirt6 activator, could be translated into an alternative microbiota-targeted avenue for coping with PSD.
Authors
- Yang Yi (ORCID: https://orcid.org/0000-0001-7186-0962)
- Fangqin Hou
- Yuandong Zhang (ORCID: https://orcid.org/0000-0003-1347-6270)
- Qihai Gong (ORCID: https://orcid.org/0000-0002-8967-337X)
- Feng Shi (ORCID: https://orcid.org/0000-0002-1850-7796)
- Jianmei Gao (ORCID: https://orcid.org/0000-0001-5544-7748)
- Xiaoyu Wu (ORCID: https://orcid.org/0009-0002-5426-5373)
- Y.L. He (ORCID: https://orcid.org/0009-0003-1035-4347)
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1016/j.jare.2025.03.002
- Citations
- 15
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 23.36