Alpha- and beta-melanocyte stimulating hormone positively impact lipogenesis of meibomian gland cells in vitro and ex vivo
Our data show for the first time that human meibomian glands express MCRs and that stimulation/inhibition of MCRs alters cAMP response, MCR expression, and lipogenesis markers, thereby affecting the genesis of meibum. Therefore, α-/β-MSH positively impacts meibum production and should be considered in the context of changes in glandular secretion in MGD and potential treatments.
Authors
- Martin Schicht (ORCID: https://orcid.org/0000-0001-5155-5477)
- Fabian Garreis
- Ingrid Zahn (ORCID: https://orcid.org/0000-0002-6477-4940)
- Eileen Socher (ORCID: https://orcid.org/0000-0002-6239-3749)
- Friedrich Paulsen (ORCID: https://orcid.org/0000-0002-0527-0953)
- Jana Dietrich (ORCID: https://orcid.org/0000-0001-7211-3168)
- Benedikt Kleinsasser (ORCID: https://orcid.org/0000-0003-4235-2357)
- Antonio Bergua
- Thilo Schikorra
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Institut für Psychogerontologie (DE)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.biopha.2025.117937
- Citations
- 3
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 5.64