β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor
This study identifies m<sup>6</sup>A modification as a critical mechanism underlying the downregulation of OR51E2 in CRC. Activation of OR51E2 by β-ionone suppresses CRC cell proliferation and induces apoptosis by elevating intracellular calcium levels, which inhibits the MEK-ERK pathway. These findings highlight OR51E2 as a potential therapeutic target and suggest that β-ionone or m<sup>6</sup>A inhibition may represent novel strategies for CRC treatment.
Authors
- Yeonji Kim (ORCID: https://orcid.org/0000-0003-3127-5827)
- Sunghoi Hong (ORCID: https://orcid.org/0000-0003-4926-1044)
- NaNa Keum
- Min‐Jeong Shin (ORCID: https://orcid.org/0000-0002-8952-4008)
- InRyeong Lee
- Adriana Rivera‐Piza
- Seok Chung
- Sungwon Shin (ORCID: https://orcid.org/0000-0002-4564-2627)
- Hyeonmin Gil (ORCID: https://orcid.org/0000-0003-0580-764X)
- Sungyun Cho (ORCID: https://orcid.org/0009-0009-2690-2268)
- Ye Eun Yoon
- Sung‐Joon Lee (ORCID: https://orcid.org/0000-0002-0661-5255)
- Ha Lim Lee
- Ji‐Sun Kim (ORCID: https://orcid.org/0000-0002-9568-1114)
- Jina Kim (ORCID: https://orcid.org/0000-0003-1684-4219)
- Jaeeun Shin (ORCID: https://orcid.org/0000-0003-3089-9347)
- Yong Hun Jung (ORCID: https://orcid.org/0000-0001-8531-7039)
- Jungwon Choi (ORCID: https://orcid.org/0000-0001-5335-496X)
- Chunyan Wu (ORCID: https://orcid.org/0000-0002-2489-9634)
- Sung‐Gil Chi
- Min-Goo Lee
- Mi-Young Jeong
- Da-In Lee (ORCID: https://orcid.org/0000-0001-7507-7086)
Institutions
- Pohang University of Science and Technology (KR)
- Korea University (KR)
- Dongguk University (KR)
- Cornell University (US)
- Department of Public (IN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1016/j.phymed.2025.156599
- Citations
- 1
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 1.31