Macrophage-derived IL-15 imprints peritoneal TRM-like CD8 T cells in cirrhosis and spontaneous bacterial peritonitis
Patients with decompensated cirrhosis exhibit impaired immune responses increasing the risk of spontaneous bacterial peritonitis. This study provides insight into a subset of human peritoneal CD8 T cells in patients with decompensated cirrhosis that have a long-lived and tissue-resident phenotype capable of effectively fighting recognised pathogens within a short period with the help of IL-15 produced by activated macrophages in a bystander fashion. This knowledge has the potential to improve immunomodulatory therapies aiming to enhance peritoneal immune surveillance, and by targeting TRM-like cells and/or IL-15 signalling pathways. In addition, high concentrations of soluble immune checkpoints in ascites should be considered when applying immune checkpoint inhibitors in decompensated cirrhosis.
Authors
- Sven Stengel (ORCID: https://orcid.org/0009-0005-1564-9835)
- Karsten Große (ORCID: https://orcid.org/0000-0003-1013-6297)
- Johanna Reißing
- Michael Rooney (ORCID: https://orcid.org/0000-0003-2648-8799)
- Tony Bruns (ORCID: https://orcid.org/0000-0002-5576-6914)
- Yulia Alexandrowna Nevzorova (ORCID: https://orcid.org/0000-0003-1390-8002)
- Sabine Baumgart (ORCID: https://orcid.org/0000-0001-8861-0388)
- Raquel Benedé‐Ubieto (ORCID: https://orcid.org/0000-0003-1779-8832)
- Stefanie Quickert (ORCID: https://orcid.org/0009-0009-9391-4111)
- Mick Frissen
- Oluwatomi Ibidapo-Obe
- Hector Leal-Lassalle
- Trong-Hieu Nguyen
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101381
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Deutsche Forschungsgemeinschaft
- Ministerio de Economía y Competitividad
- RWTH Aachen University
- Fundación Para La Innovación Y La Prospectiva En Salud En España
- Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg
- Agencia Estatal de Investigación