Exploring the Impact of Serum Growth Factors in the Pathogenesis of Acute and Chronic Myeloid Leukemia

Objective: The aim of this study is to assess the potential association between the amounts of serum growth factors and the risk of developing acute and chronic myeloid leukemia. Methods: The research comprised 168 participants, aged between 21 and 69 of these, 52 were diagnosed with acute myeloid leukemia, while 71 had chronic myeloid leukemia from Hiwa Hospital in Sulaymaniyah. Moreover, 45 healthy individuals, matched for age and gender, were also recruited to act as controls in the study. The levels of Basic fibroblast growth factor, Insulin-like growth factor I, Vascular endothelial growth factor, Hepatocyte growth factor, Platelet-Derived Growth Factor and Transforming growth factor-β in the serum were evaluated using the sandwich enzyme-linked immunosorbent assay (ELISA) method, employing kits produced by RayBiotech company. Results: Between the patient groups and the healthy control group, the mean values for the study parameters were compared using a one-way ANOVA. The serum levels of all mentioned growth factors showed significantly elevation in patients comparing to controls. Conclusion: Serum Basic fibroblast growth factor and other growth factors might be a potential complementary biomarker for acute myeloid leukemia and chronic myeloid leukemia.