Investigating of the physico-chemistry thiolated dextran derivatives
The study aimed to create redox-responsive dextran carriers for controlled hydrophobic molecule release using glutathione, a natural cellular reducing agent, by modifying dextran with a thiol derivative. Investigating the impact of different hydrophobic length on the molecular self-organization of polysaccharide derivatives into nanoparticles helped to understand their roles in this process. The study demonstrated that thiolated dextran particles can be used as emulsifier and can effectively encapsulated hydrophobic molecules like Nile red dye, with the disulfide linkage being cleaved by glutathione under physiological conditions for rapid release. Additionally, the dextran-based particles were found to be non-toxic to living cells.
Authors
- Angélique Goffin (ORCID: https://orcid.org/0000-0002-6537-0999)
- Alexandre Hinzpeter (ORCID: https://orcid.org/0000-0001-6920-7761)
- Cléa Chesneau
- Sabrina Belbekhouche (ORCID: https://orcid.org/0000-0002-0636-4425)
- Loren Jørgensen (ORCID: https://orcid.org/0000-0002-2775-8415)
- A. Pelletier
- Madara Dias Wickramanayaka
Institutions
- Centre National de la Recherche Scientifique (FR)
- École nationale des ponts et chaussées (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Laboratoire Eau, Environnement et Systèmes Urbains (FR)
- Sciences et Ingénierie de la Matière Molle (FR)
- Institut de Chimie et des Matériaux Paris-Est (FR)
Publication Details
- Journal
- Colloids and Surfaces B Biointerfaces
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.colsurfb.2025.114603
- Citations
- 2
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.19
Funders
- Agence Nationale de la Recherche