A composite 18F-FDG PET/CT and HER2 tissue-based biomarker to predict response to neoadjuvant pertuzumab and trastuzumab in HER2-positive breast cancer (TBCRC026)
The HER2/PET-CT biomarker had high prediction power for pCR, however was not superior to the prediction power of PET/CT alone. Non-invasive PET/CT biomarkers may facilitate a response-guided approach to neoadjuvant therapy, allowing intensification and de-intensification of treatment, pending further evaluation.
Authors
- Roisín M. Connolly (ORCID: https://orcid.org/0000-0003-0056-1070)
- Jodi M. Carter (ORCID: https://orcid.org/0000-0002-5973-0732)
- Lilja B. Sólnes (ORCID: https://orcid.org/0000-0002-2192-7425)
- Richard L. Wahl (ORCID: https://orcid.org/0000-0002-7306-2590)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- E. Aubrey Thompson
- Antonio C. Wolff (ORCID: https://orcid.org/0000-0003-3734-1063)
- Ian E. Krop (ORCID: https://orcid.org/0000-0002-6380-5944)
- Rita Denbow (ORCID: https://orcid.org/0000-0002-6603-3863)
- Maeve Hennessy (ORCID: https://orcid.org/0000-0002-2369-3327)
- Ashley Cimino‐Mathews (ORCID: https://orcid.org/0000-0002-0638-7969)
- Lisa A. Carey (ORCID: https://orcid.org/0000-0003-2388-4649)
- Anna Maria Storniolo (ORCID: https://orcid.org/0000-0002-8701-7889)
- Vered Stearns (ORCID: https://orcid.org/0000-0003-4018-4708)
- Christos Vaklavas (ORCID: https://orcid.org/0000-0002-9919-2748)
- Eric P. Winer (ORCID: https://orcid.org/0000-0002-8819-1723)
- Jennifer M. Kachergus
- Mothaffar F. Rimawi (ORCID: https://orcid.org/0000-0002-4284-5656)
- Chiung‐Yu Huang (ORCID: https://orcid.org/0000-0003-2313-3562)
- Vandana G. Abramson (ORCID: https://orcid.org/0000-0002-6855-1322)
- V. Valero
- Yaohua Ma (ORCID: https://orcid.org/0000-0003-4402-5464)
- Jeffrey P. Leal (ORCID: https://orcid.org/0000-0002-8774-4541)
Institutions
- University of North Carolina at Chapel Hill (US)
- Indiana University Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- University of Alberta (CA)
- Baylor College of Medicine (US)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- University College Cork (IE)
- Yale Cancer Center (US)
- University of Alabama at Birmingham (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- The Breast
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.breast.2025.104432
- Citations
- 2
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09