Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens
Our findings highlighted a novel concept of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>r</mml:mi> <mml:mrow><mml:mi>b</mml:mi></mml:mrow> <mml:mn>2</mml:mn></mml:msubsup> </mml:math> to quantify the phenotypic variance attributed to gene expression and emphasize the superior role of intestinal mucosal gene expressions over host genomic variations in elucidating host‒microbe interactions for complex traits. This understanding could assist in devising strategies to modulate host-microbe interactions, ultimately improving economic traits in chickens.
Authors
- Fangren Lan (ORCID: https://orcid.org/0009-0005-9637-7762)
- Chaoliang Wen (ORCID: https://orcid.org/0000-0002-0514-2847)
- Jiaming Jin
- Xiaochang Li (ORCID: https://orcid.org/0000-0002-6203-7197)
- Congjiao Sun
- Wenxin Zhang (ORCID: https://orcid.org/0000-0001-9937-6240)
- Guiqin Wu (ORCID: https://orcid.org/0000-0001-5422-4323)
- Ning Yang (ORCID: https://orcid.org/0000-0001-5772-3320)
- Qianqian Zhou (ORCID: https://orcid.org/0000-0003-0152-4407)
- Guangqi Li (ORCID: https://orcid.org/0000-0003-3002-4778)
- Yiyuan Yan
- Xiqiong Wang
Institutions
- Ministry of Agriculture and Rural Affairs (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s40168-025-02054-5
- Citations
- 3
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China