The Effect of High-Intensity Functional Training on Semaphorin-3E Levels in Obese Men

Objective: The role of inflammation in the pathophysiology of obesity is significant, as a known connection between metabolism and immune function. Lifestyle modification may be a useful strategy to prevent obesity- related complications. To the best of our understanding, there have been no studies conducted to examine the impact of various exercise protocols on the profile of inflammatory factors within the body. The objective of this study was to examine the impact of high-intensity functional training (HIFT) on the levels of semaphorin- 3E (Sema-3E) in individuals who are obese. Materials and Methods: This study examined the effects of a 12-week HIFT program on 22 obese men aged 23 to 32 years old. Participants were divided into two groups: a control group (C) and a HIFT exercise group (H). Body mass index (BMI) and blood levels of Sema-3E were measured before and after the intervention period. Results: In this study, the results of the ANOVA analysis showed a significant difference of the levels of semaphorin-3E between the studied groups (P< 0.001). Conclusion: The results of the present study show that HIFT reduced the levels of semaphorin-3E in the body and may be effective in reducing systemic inflammation.