Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions
This study clarifies that DKK1 mediates interactions between cancer cells and fibroblasts in gefitinib-resistant lung cancer, contributing to tumor progression. Therefore, we propose DKK1 as a promising anticancer target for the treatment of gefitinib-resistant NSCLC.
Authors
- Yujeong Lee
- Yong June Choi (ORCID: https://orcid.org/0009-0009-8661-4815)
- Keon Wook Kang (ORCID: https://orcid.org/0000-0003-2622-9017)
- Munkyung Choi (ORCID: https://orcid.org/0000-0001-9712-7232)
- Young Ju Lee (ORCID: https://orcid.org/0000-0001-5294-7368)
- Jin Haeng Chung
Institutions
- Seoul National University (KR)
- Seoul National University Bundang Hospital (KR)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s40164-025-00616-9
- Citations
- 3
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Research Foundation of Korea