Can the single-breath alveolar volume be adjusted to estimate true total lung capacity?

After adjustment TLCsb was no longer significantly underestimated in obstructive and mixed restrictive-obstructive groups compared to TLCwbp. The adjustment can be used on individual subjects to estimate restriction via the TLCsb, thereby making the single-breath gas diffusion method a more valid alternative than without adjustment, when compared with the gold standard whole-body plethysmography to measure TLC.

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Publication Details

Journal
European Clinical Respiratory Journal
Published
2025-03-01
DOI
https://doi.org/10.1080/20018525.2025.2470002
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
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article

Can the single-breath alveolar volume be adjusted to estimate true total lung capacity?

Jann Mortensen, Simon Kristoffer Høgh Rasmusen
1 links
European Clinical Respiratory Journal
Chronic Obstructive Pulmonary Disease (COPD) Research
article

Can the single-breath alveolar volume be adjusted to estimate true total lung capacity?

Jann Mortensen, Simon Kristoffer Høgh Rasmusen
article en

Abstract

After adjustment TLCsb was no longer significantly underestimated in obstructive and mixed restrictive-obstructive groups compared to TLCwbp. The adjustment can be used on individual subjects to estimate restriction via the TLCsb, thereby making the single-breath gas diffusion method a more valid alternative than without adjustment, when compared with the gold standard whole-body plethysmography to measure TLC.

European Clinical Respiratory JournalVol. 12(1)
University of the Faroe Islands (FO), University of Copenhagen (DK), Copenhagen University Hospital (DK), Rigshospitalet (DK), National Hospital (IN), National Hospital for Neurology and Neurosurgery (GB), University College London (GB)
Openalex Percentile: Top 94%
Chronic Obstructive Pulmonary Disease (COPD) Research
DOIOpen Access PDFOpenAlex
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