Indole-3-propionic acid promotes hepatic stellate cells inactivation
In conclusion, these data support that IPA has a plausible therapeutic effect and may induce apoptosis and the HSC phenotype towards the inactivation state, extending the possibilities to suppress hepatic fibrogenesis by interfering with HSC activation and mitochondrial metabolism.
Authors
- Ratika Sehgal (ORCID: https://orcid.org/0000-0002-4817-243X)
- Stefano Romeo (ORCID: https://orcid.org/0000-0001-9168-4898)
- Eija Pirinen (ORCID: https://orcid.org/0000-0003-1495-3972)
- Maija Vaittinen (ORCID: https://orcid.org/0000-0002-7423-557X)
- Kirsi Rilla (ORCID: https://orcid.org/0000-0002-7862-5727)
- Ville Männistö (ORCID: https://orcid.org/0000-0002-0735-400X)
- Charlotte Ling (ORCID: https://orcid.org/0000-0003-0587-7154)
- Kirsi Hannele Pietiläinen (ORCID: https://orcid.org/0000-0002-8522-1288)
- Mariana Ilha (ORCID: https://orcid.org/0000-0001-9741-8865)
- Jussi Pihlajamäki (ORCID: https://orcid.org/0000-0002-6241-6859)
- S.P. Gandhi (ORCID: https://orcid.org/0000-0002-7079-1886)
- Päivi Pajukanta (ORCID: https://orcid.org/0000-0002-6423-8056)
- Kirsi A. Virtanen (ORCID: https://orcid.org/0000-0001-6183-4525)
- Johanna Matilainen (ORCID: https://orcid.org/0000-0001-7239-2128)
- Dorota Kamińska (ORCID: https://orcid.org/0000-0003-1829-576X)
Institutions
- Scania (Sweden) (SE)
- University of Helsinki (FI)
- University of Turku (FI)
- University of California, Los Angeles (US)
- University of Eastern Finland (FI)
- Lund University (SE)
- University of Münster (DE)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Kuopio University Hospital (FI)
- Turku PET Centre (FI)
- German Institute of Human Nutrition (DE)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
- University of Oulu (FI)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s12967-025-06266-z
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Itä-Suomen Yliopisto
- Helsingin Yliopisto
- Suomen Lääketieteen Säätiö
- European Foundation for the Study of Diabetes
- Academy of Finland
- Lunds Universitet
- Jane ja Aatos Erkon Säätiö
- Vetenskapsrådet
- China Scholarship Council
- Novo Nordisk Fonden
- Region Skåne
- Diabetestutkimussäätiö
- Biocenter Finland
- National Institutes of Health