Impact of transmurality and location on the diagnostic performance of 13N-ammonia positron emission tomography in the detection of myocardial fibrosis – A hybrid positron emission tomography/magnetic resonance study
PET yields high sensitivity for the detection of left ventricular (LV) myocardial fibrosis of ischemic or inflammatory etiology on a per-patient basis. However, compared to CMR, the overall fibrosis extent is significantly underestimated because, on a segmental level, sensitivities are significantly lower for fibrosis with lower transmurality and those located subepicardial and midmyocardial, as compared to subendocardial.
Authors
- Pascal S. Heiniger (ORCID: https://orcid.org/0000-0002-7279-6330)
- Aju P. Pazhenkottil (ORCID: https://orcid.org/0000-0002-8847-2154)
- Dominik C. Benz (ORCID: https://orcid.org/0000-0001-8627-726X)
- Marko Gajic
- Philipp Antonio Kaufmann (ORCID: https://orcid.org/0000-0002-9451-5210)
- Ronny R. Buechel (ORCID: https://orcid.org/0000-0001-8064-8904)
- Andreas A. Giannopoulos (ORCID: https://orcid.org/0000-0002-0938-3170)
- Andrei Galafton (ORCID: https://orcid.org/0009-0007-5568-5069)
- Tobia Albertini
- Stjepan Jurisic (ORCID: https://orcid.org/0000-0003-3126-8555)
- Gian Diego Igual
- Rita Pingree
Institutions
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Journal of Nuclear Cardiology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.nuclcard.2025.102172
- Citations
- 3
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.08