Tas2r123-associated mitochondrial organization and neuroplasticity underlying the antidepressant effect of resveratrol
Our findings suggest that resveratrol may exert antidepressant property by modulating neuroplasticity through the Tas2r123-mitochondrial organization pathway. This study introduces a novel perspective linking Tas2rs to resveratrol's antidepressant mechanisms, potentially pave the way for future antidepressant therapies.
Authors
- Gaohua Wang (ORCID: https://orcid.org/0000-0002-8947-9921)
- Junjie Huang (ORCID: https://orcid.org/0000-0003-4184-9505)
- Lujia Si
- Limin Sun (ORCID: https://orcid.org/0000-0003-1224-4320)
- Yinping Xie (ORCID: https://orcid.org/0000-0002-1450-5822)
- Hailong Ge (ORCID: https://orcid.org/0000-0002-8349-985X)
- Chen Li (ORCID: https://orcid.org/0000-0003-1947-0881)
- Ling Xiao (ORCID: https://orcid.org/0000-0003-2291-9459)
- Lan Wu (ORCID: https://orcid.org/0000-0002-5677-7658)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111271
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.73