Unveiling tumor-infiltrating immune cell-driven immune-mediated drug resistance in clear cell renal cell carcinoma: prognostic insights and therapeutic strategies
Our findings underscore the pivotal role of TIIC-RNAs in mediating drug resistance in ccRCC. The prognostic model provides valuable insights into immune and metabolic mechanisms underlying therapy resistance, offering a foundation for developing precision therapeutics targeting the TME.
Authors
- Jiusong Luan
- Yanhua Tian (ORCID: https://orcid.org/0000-0001-7095-8765)
- Haisong Zhang (ORCID: https://orcid.org/0009-0008-0567-3673)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-8582-1128)
- Wenbo Yang (ORCID: https://orcid.org/0000-0002-9268-2314)
- Jifeng Yang
- Yixuan Xing
Institutions
- Hebei Medical University (CN)
- Central South University (CN)
- Second Hospital of Hebei Medical University (CN)
- Affiliated Hospital of Hebei University (CN)
- Xiangya Hospital Central South University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s12672-025-01890-z
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00