Fresh vs Frozen Embryo Transfer Cycle Clinical Outcome after Controlled Ovarian Stimulation in GnRH Agonist Protocol: Retrospective Cohort Study

Background:In gonadotropin-releasing hormone (GnRH)-antagonist protocols, several studies have examined live birth rates after frozen embryo transfer (FET) and ET, and they have always shown that the two methods are equivalent or even better.The relative merits of fresh vs FET in GnRH agonist regimens, however, have been the subject of little research.This study seeks to determine which treatment approach yields better clinical outcomes for patients undergoing GnRH agonist protocols.Materials and methods: This retrospective research focuses on women who had intracytoplasmic sperm injections or in vitro fertilization and went on to have either E/T or FET.Around 150 patients took part in the FET rounds, whereas 158 people took part in the first fresh ET cycle.These individuals were all treated with GnRH, which was a lengthy procedure, and on the third day, embryos were transferred.Results: Statistical analysis revealed no significant difference between the two groups in terms of the clinical pregnancy rate, which was 46.2% after FET and 52% after fresh embryo transfer (ET), and the pregnancy loss rate, which was 13.3% after Fresh ET and 20.4% after FET.The live delivery rate was 32.3% in the fresh ET group and 30.6% in the FET cycle, as shown by the p-value of 0.666. Conclusion:In considering the fact that both the fresh and frozen cycles provide identical outcomes, this research implies that an individualized approach is necessary prior to choosing the protocol, and not everyone should adhere to the freeze-all technique.