Stratification of the immunotypes of tongue squamous cell carcinoma to improve prognosis and the response to immune checkpoint inhibitors
We defined five TSCC-specific immunotypes based on the results of comprehensive immune profiling analyses. Immunoactive type, which would be sensitive to ICI monotherapy, was rare, and most TSCC cases exhibited immune-regulated immunotypes. Immunotype-based personalized treatments are required to improve clinical outcomes.
Authors
- Fumihiko Tsushima (ORCID: https://orcid.org/0000-0002-1919-746X)
- Tohru Ikeda (ORCID: https://orcid.org/0000-0002-3615-5421)
- Yun Su (ORCID: https://orcid.org/0000-0003-4397-3278)
- Pissacha Daroonpan (ORCID: https://orcid.org/0000-0003-2366-6668)
- Yoshihito Kano (ORCID: https://orcid.org/0000-0001-7511-7009)
- Takahiro Asakage
- Makoto Noguchi (ORCID: https://orcid.org/0009-0007-4116-1045)
- Miwako Hamagaki
- Miyuki Azuma (ORCID: https://orcid.org/0000-0002-3529-4585)
- Naoto Nishii
- Ryo Ouchi
- Hiroyuki Harada (ORCID: https://orcid.org/0000-0002-8078-0195)
- Rika Nagamine
Institutions
- Tokyo Medical and Dental University (JP)
- Tokyo University of Science (JP)
- University of Toyama (JP)
- Naresuan University (TH)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s00262-025-03982-9
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18