Lipidomics-based plasma signature of alcohol-related hepatitis linked to short-term mortality
Lipids can act as mediators at the interface between the immune system and metabolism, potentially contributing to the pathogenesis and outcomes of patients with severe alcohol-related hepatitis, prompting us to investigate lipidomic changes in this population using untargeted approaches, compared with patients with decompensated cirrhosis. This study highlights a distinct lipidomic signature in patients with severe alcohol-related hepatitis compared with decompensated cirrhosis, primarily involving glycerophospholipids and sphingolipids. Specific lipid classes, such as acylcarnitines, suggest significant mitochondrial dysfunction and are associated with disease severity and short-term mortality in patients with severe alcohol-related hepatitis. These findings underscore the importance of targeted investigations into these lipid species, their pathways, and their links to disease severity and outcomes, particularly in this condition that currently lacks specific treatments.
Authors
- Phillip E. Morgan (ORCID: https://orcid.org/0000-0002-8871-4352)
- Alexandros Pechlivanis (ORCID: https://orcid.org/0000-0002-3448-2461)
- Maura Morrison
- Mark R. Thursz (ORCID: https://orcid.org/0000-0002-8218-192X)
- Elaine Holmes (ORCID: https://orcid.org/0000-0002-0556-8389)
- Salma Mujib (ORCID: https://orcid.org/0000-0002-9962-1960)
- Nikhil Vergis (ORCID: https://orcid.org/0000-0002-4157-6757)
- Florent Artru (ORCID: https://orcid.org/0000-0002-2220-6646)
- Robert Goldin (ORCID: https://orcid.org/0000-0001-5184-4519)
- Noora Kano
- Luke D. Tyson (ORCID: https://orcid.org/0000-0003-2745-0282)
- María Gómez‐Romero (ORCID: https://orcid.org/0000-0003-4884-7721)
- Mark McPhail (ORCID: https://orcid.org/0000-0001-5449-2424)
- Evangelos Triantafyllou (ORCID: https://orcid.org/0000-0002-2755-9619)
- Roosey Sheth
- Stephen Douglas Atkinson (ORCID: https://orcid.org/0000-0002-7180-6672)
- Vishal Patel (ORCID: https://orcid.org/0000-0001-6616-3628)
- Anna Cavazza (ORCID: https://orcid.org/0000-0003-3720-0463)
- Francesca M. Trovato (ORCID: https://orcid.org/0000-0002-8048-1646)
- Marc Zentar
- Alberto Quaglia (ORCID: https://orcid.org/0000-0002-3333-3579)
- Ellen Jerome
Institutions
- King's College London (GB)
- Hammersmith Hospital (GB)
- Université Rennes 2 (FR)
- Foundation for Liver Research (GB)
- St Mary's Hospital (GB)
- King's College Hospital (GB)
- Centre Hospitalier Universitaire de Rennes (FR)
- Imperial College London (GB)
- Université de Rennes (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101367
- Citations
- 2
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- Imperial College London
- King's College London
- Centre Hospitalier Universitaire de Rennes
- Medical Research Council
- NIHR Imperial Biomedical Research Centre