Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism
We find that apoA-IV is potently increased by intake of fat in humans, and that several beneficial metabolic effects, previously associated with high fat intake in humans, are mimicked by administration of apoA-IV protein to mice.
Authors
- Andreas M. Fritzen (ORCID: https://orcid.org/0000-0001-8793-9739)
- Mark Larance (ORCID: https://orcid.org/0000-0002-8579-2267)
- Michael M. Richter (ORCID: https://orcid.org/0000-0002-3861-8469)
- Rita Del Giudice
- Kim A. Sjøberg (ORCID: https://orcid.org/0000-0001-6880-4804)
- Anne‐Marie Lundsgaard
- Kirstine N. Bojsen‐Møller (ORCID: https://orcid.org/0000-0003-1962-5302)
- Bente Kiens (ORCID: https://orcid.org/0000-0001-5705-5625)
- Christian S. Carl (ORCID: https://orcid.org/0000-0002-9551-5837)
- Jakob G. Knudsen (ORCID: https://orcid.org/0000-0001-7237-8457)
- Nicoline R. Andersen (ORCID: https://orcid.org/0000-0002-1512-2727)
- Amalie London (ORCID: https://orcid.org/0000-0003-1708-9809)
- Jens O. Lagerstedt
- Trine S. Nicolaisen (ORCID: https://orcid.org/0000-0001-5856-6443)
- Josephine M. Kanta (ORCID: https://orcid.org/0000-0002-0428-0973)
- Sarah Armour
Institutions
- University of Copenhagen (DK)
- The University of Sydney (AU)
- Lund University (SE)
- Novo Nordisk (Denmark) (DK)
- Frederiksberg Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.molmet.2025.102119
- Citations
- 6
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 7.77
Funders
- Hjerteforeningen
- Sundhed og Sygdom, Det Frie Forskningsråd
- Danish Diabetes Academy
- Københavns Universitet
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden