RANKL-derived peptide MHP1-AcN attenuates ovariectomy-induced osteoporosis by targeting RANK and TNFR1 in mice
MHP1-AcN effectively inhibits osteoclastogenesis and sclerostin-mediated suppression of bone formation while considerably preserving osteoblast function. These findings suggest that MHP1-AcN, which targets dual pathways critical for bone homeostasis, is a promising uncoupling therapeutic agent for osteoporosis.
Authors
- Nagahiro Ochiai
- Atsushi Sugimoto (ORCID: https://orcid.org/0000-0003-3311-2562)
- Yuji Fukuda (ORCID: https://orcid.org/0000-0002-3889-0999)
- Yuki Etani (ORCID: https://orcid.org/0000-0001-5741-5969)
- Takaaki Noguchi (ORCID: https://orcid.org/0000-0001-9938-6780)
- Taihei Miura
- Ken Nakata (ORCID: https://orcid.org/0000-0002-8964-4229)
- Kosuke Ebina (ORCID: https://orcid.org/0000-0002-2426-1024)
- Munehisa Shimamura (ORCID: https://orcid.org/0000-0003-0374-0787)
- Makoto Hirao (ORCID: https://orcid.org/0000-0002-1408-7851)
- Seiji Okada (ORCID: https://orcid.org/0000-0002-5107-8209)
- Atsushi Goshima (ORCID: https://orcid.org/0000-0002-0729-668X)
- Nan Ju (ORCID: https://orcid.org/0000-0003-3421-7104)
- Takashi Kanamoto (ORCID: https://orcid.org/0000-0001-6689-7277)
- Satoshi Yamakawa
- Takuya Kurihara (ORCID: https://orcid.org/0009-0005-3892-123X)
Institutions
- Kisarazu Hospital (JP)
- Osaka Rosai Hospital (JP)
- Osaka Minami Medical Center (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Bone
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.bone.2025.117440
- Citations
- 7
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.64