Phytochemical composition, acute and subacute toxicity profile of Persea amaricana seed oil in albino Wistar rats
Our study showed that the LD<sub>50</sub> of PASO is 1477.83 mg/kg body weight, which classifies it as a moderately toxic substance. In subacute toxicity, our results revealed that treatment with PASO resulted in an increase in liver enzymes, urea and creatinine, and inflammatory markers, and a decrease in antioxidant enzymes, suggesting that PASO impairs liver and kidney functions and may cause cardiac or muscle damage in albino Wistar rats.
Authors
- Benedict Chukwuebuka Okoro (ORCID: https://orcid.org/0000-0002-0392-9080)
- Omoremime Elizabeth Dania (ORCID: https://orcid.org/0000-0002-1713-3999)
- Eziuche Amadike Ugbogu (ORCID: https://orcid.org/0000-0003-3145-5473)
- Emeka Iweala (ORCID: https://orcid.org/0000-0002-1393-1416)
- Doris Nnenna Amuji (ORCID: https://orcid.org/0009-0009-9808-2297)
- Finian Uchenna Okore
Institutions
- Abia State University (NG)
- Covenant University (NG)
Publication Details
- Journal
- Toxicology Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.toxrep.2025.101982
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00