Fluorescent half-salen phenoxy-imine zinc complexes to reveal exogenous and endogenous H2S
In this contribution, the synthesis and the reactivity with HS<sup>-</sup> of a family of half-salen Zn complexes are reported. We provide evidence that HS<sup>-</sup> binds the zinc center of all the complexes under investigation. DFT and CCSD(T) calculations were performed to model the reactivity of these complexes with HS<sup>-</sup>. We successfully applied a homoleptic zinc complex bearing a Schiff-based ligand with pyridine pendant arms as a probe for the monitoring of exogenous and endogenous H<sub>2</sub>S levels in live cells.
Authors
- Maria Strianese (ORCID: https://orcid.org/0000-0002-6180-872X)
- Giuseppe Gravina (ORCID: https://orcid.org/0000-0003-1423-0221)
- Mina Mazzeo (ORCID: https://orcid.org/0000-0003-4683-7642)
- Viktoriia Vykhovanets
- Marina Lamberti (ORCID: https://orcid.org/0000-0002-9118-0048)
- Daniela Guarnieri (ORCID: https://orcid.org/0000-0002-0947-7724)
- Andrea Maranzana (ORCID: https://orcid.org/0000-0002-5524-8068)
- Naym Blal (ORCID: https://orcid.org/0000-0002-9420-0761)
- Alessio Trerotola
Institutions
- University of Salerno (IT)
- University of Turin (IT)
Publication Details
- Journal
- Journal of Inorganic Biochemistry
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jinorgbio.2025.112875
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Torino
- Università degli Studi di Salerno